Tor Erik Rusten
Date: April 26, 2018. 12:00
Location: CCU Seminar Room
Title: Autophagy and tumorigenesis, lessons from Drosophila
Affiliation: Oslo University Hospital, Norway.
The catabolic process of autophagy is dysregulated during carcinogenesis and mutations in core components of the autophagic machinery are linked to carcinogenesis in humans.
To understand more about this relationship, we have pursued the importance of autophagy and its machinery during tumorigenesis using the animal model system Drosophila melanogaster.
I will present findings from our lab that uncover 1) A role for autophagy to support tumor growth from the tumor microenvironment, and 2) A tumor suppressor function of the autophagy regulator PI3K-III.
Microenvironmental autophagy supports tumor growth, Katheder, N. et al, nature 2017. PMID 28077876
Class III Phopshatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1regulation, O’Farrel, F. et al, nature cell biology, 2017, PMID 29084199