Date: September 20, 2018. 12:00
Location: CCU Seminar Room
Title: RNA regulation of the Innate Immune System.
Affiliation: University of Pennsylvania, USA.
Epigenetic modifications induced by extracellular cues enable cells to rapidly adapt to changes in their environment. Long non-coding RNAs (lncRNAs) are now considered
key controllers of epigenetically regulated gene expression. Notably, emerging evidence indicates that lncRNAs play a critical role in integrating extracellular inputs with epigenetic modification pathways to promote changes in gene expression programs. Given the tight regulation that is required to maintain innate immune cells on check and prevent the development immunopathology, we propose that mononuclear phagocytes specifically express lncRNAs that are required to finely tune these cells to their environment, to both promote anti-pathogen immunity and prevent immunopathology. In here, we combined a novel bioinformatic workflow with the CRISPR/Cas9 system to provide evidence that rapid and local regulation of gene expression by lncRNAs in response to extracellular cues is a powerful and potentially generalizable mechanism through which optimal immune cell homeostasis is achieved.