Date: March 15, 2018. 12:00
Location: CCU Seminar Room
Title: Cortical dynamics drive continuous recombination of cell assemblies in mouse auditory cortex.
Affiliation: University Medical Center of the Johannes Gutenberg University Mainz, Germany.
Chronic imaging studies of synapses in the living animal have highlighted the fact that the connections of cortical microcircuits undergo substantial remodeling, even under conditions that do not require behaviorally or pathologically induced adaptation. This raises the question how stable or dynamic sensory representation are over the time-course of multiple days. In order to address this question, we have chronically measured sound-evoked responses in several thousands of neurons in the mouse auditory cortex. We observe that, similar to the dynamics at the synaptic level, also sensory representations undergo significant remodeling while maintaining overall representational power. Monitoring the continuous dynamics reveals a basis set of operations for the recombination of cell assemblies.