Andrés Hidalgo Alonso
Date: May 21, 2019. 15:00
Location: CCU Seminar Room
Title: Innate Immunity and Tissue Homeostasis
Affiliation: The Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
Metazoan organisms thrive through the combined actions of specialized parenchymal cells than form tissues of defined functions. A special case is that of immune cells, such as lymphocytes, which may not have a unique localization but rather patrol and interact with cells across all tissues to confer anti-microbial protection. Even more particular, innate immune cells share mixed features and acquire tissue-specific properties but are also avid patrollers of the body. We focus much of our work on neutrophils and macrophages, two types of innate immune cells. We study patterns of migration and normal or pathological functions of neutrophils in vessels and organs. We also study new aspects of their biology, namely the acquisition of tissue-tailored phenotypes and functions with the ultimate goal of defining non-immune roles of these leukocytes in certain tissues. We argue that the genetic plasticity of these cells is key to gain such a diverse array of functions, and to ultimately support organismal health.