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Christa Rhiner

  1. Christa Rhiner, PhD
    Principal Investigator

  2. Dr. Rhiner received her Master degree in 2012 from the University of Bern, Switzerland, after having performed her Master project in the lab of Prof. Adriano Aguzzi at the University Hospital in Zurich. Then, she entered the International Neuroscience PhD program of the ETH/University of Zurich (UZH) and joined the lab of Prof. Michael O. Hengartner at the Institute of Molecular Life Sciences at UZH for PhD studies on nervous system development and axon guidance in C. elegans (2002-2006). During this time, she also acquired a degree in science communication from the UZH and Institute for Applied Media Studies in Winterthur. From 2007 to 2010 she was a postdoctoral fellow in the group of Dr. Eduardo Moreno at the National Cancer Center (CNIO) in Madrid, where she identified and characterized key genes mediating cell competition in Drosophila and mice. In 2011, Dr. Rhiner became a lecturer and investigator at the IZB in Bern, Switzerland, where she worked on neuronal selection and began to study regenerative neurogenesis in Drosophila. In 2016, she moved to Portugal to start her own group at the Champalimaud Center in Lisbon focusing on stem cell control and regeneration.

Key publications

  • Dina S. Coelho, Silvia Schwartz, Marisa M. Merino, Barbara Hauert, Barbara Topfel, Christa Rhiner and Eduardo Moreno (2018) Culling less fit neurons protects against amyloid-Beta-induced brain damage and cognitive and motor decline Cell Rep
  • Schwartz S and Rhiner C (2018) Reservoirs for Repair? Damage-responsive stem cells and adult tissue regeneration in Drosophila. Int. J. Dev. Biol.
  • Simões AR, Rhiner C (2017) A Cold-Blooded View on Adult Neurogenesis Front Neurosci
  • Merino MM, Rhiner C, Lopez-Gay JM, Buechel D, Hauert B, Moreno E (2015) Elimination of unfit cells maintains tissue health and prolongs lifespan Cell
  • Moreno E, Fernandez-Marrero Y, Meyer P, Rhiner C. (2015) Brain regeneration in Drosophila involves comparison of neuronal fitness. Curr. Biol.
  • Merino MM, Rhiner C, Portela M, Moreno E (2013) "Fitness fingerprints" mediate physiological culling of unwanted neurons in Drosophila Curr. Biol.
  • Rhiner C, López-Gay JM, Soldini D, Casas-Tinto S, Martín FA, Lombardía L, Moreno E (2010) Flower Forms an Extracellular Code that Reveals the Fitness of a Cell to its Neighbors in Drosophila Dev. Cell